Integrated Structural Biology (ISB) Core

Mission Statement

The Integrated Structural Biology (ISB) Core operated by the Center for Biomolecular Structure and Dynamics and is funded by an NIH CoBRE grant, University support funds and in future, in part, by user fees. The goal of the core is to provide support, expertise, and infrastructure to UM laboratories that use X-ray crystallography as a tool to determine the three-dimensional atomic structures of the biological macromolecules for their research projects. We offer expertise and guidance on protein expression, purification, and crystallization for X-ray crystal structure analysis. We provide facilities for crystallization of macromolecules and evaluation of crystallization experiments and measurement of diffraction data from crystals. Computational resources of the ISB are available for X-ray data processing, structure determination, refinement, and visualization. We also measure X-ray diffraction data from crystals at synchrotron sources at single and multiple wavelengths. The Facility also provides a resource for training, education, and consultation in X-ray crystallography techniques to allow individual investigators of any experience level to initiate and successfully complete a structural biology project for their research.