Featured Core Facility: Biospectroscopy Core Research Laboratory (BCRL)

Visiting Scholar collecting and analyzing data in the BCRL Facility

To kick off 2020, we would like to bring your attention to CBSD’s Biospectroscopy Core Research Laboratory (BCRL). Directed by Professor Sandy Ross and managed by Dr. Zifan Wang, the Core offers consultation, experimental design, measurement, and data analysis on a collaborative or contractual basis. Services include imaging comprising confocal, differential interference contrast, phase contrast, bright field, and total internal reflection fluorescence microscopy; steady-state absorption and fluorescence; and time-resolved techniques comprising anisotropy, fluorescence and phosphorescence intensity decay, Förster Resonance Energy Transfer (FRET), Single-Molecule FRET (smFRET), Time-Resolved Emission Spectra (TRES), Fluorescence Correlation Spectroscopy (FCS), Dual-focus Fluorescence Correlation Spectroscopy (2fFCS), and Fluorescence Lifetime Imaging (FLIM).

As the CBSD moves into Phase III of the CoBRE, our focus will be on Core sustainability. In July 2019, Drs. Ross and Harmen Steele organized a two-day Time-Correlated Single-Photon Counting (TCSPC) Fluorescence Workshop that featured presentations by nationally and internationally renowned investigators. Support from and participation by Zeiss USA and PicoQuant GmbH was much appreciated. The Workshop was attended by 45 researchers from Montana, including undergraduate and graduate students, faculty researchers, and industry contacts. A post-event survey indicated that the Workshop lived up to the expectations of most attendees (90% of 32 responses), with several noting satisfaction with the open dialogue among experts and colleagues. We will offer comparable workshops in the near future. As a Courier subscriber, you will be kept apprised as these opportunities arise.

Like other CBSD Facilities, the NIH-CoBRE primarily supports the BCRL with additional funding provided by UM’s Vice President of Research and Creative Scholarship (VPRCS). To enhance the sustainability of the Core, it has operated as a recharge facility with an established fee structure. UM faculty members who are unable to provide funding for their use of core facilities or need to acquire preliminary data leading to publications or grant applications are encouraged to consider applying for voucher funding. Staff and students from individual research laboratories are encouraged to consult with Drs. Sandy Ross (sandy.ross@umontana.edu) and Zifan Wang (Zifan.wang@mso.umt.edu) about how the BCRL resources can advance their research programs.

 

TIRF microscope based on Nikon TE
TIRF Microscope based on Nikon TE

 

 

In July 2019, Drs. Ross and Harmen Steele organized a two-day Time-Correlated Single-Photon Counting (TCSPC) Fluorescence Workshop that featured presentations by nationally and internationally renowned investigators. The photo above was taken during the Workshop.
In July 2019, Drs. Ross and Harmen Steele organized a two-day Time-Correlated Single-Photon Counting (TCSPC) Fluorescence Workshop that featured presentations by nationally and internationally renowned investigators. The photo above was taken during the Workshop.