Xiaobo Wang Receives Predoctoral Fellowship from the American Heart Association
Xiaobo Wang received a two-year predoctoral fellowship award from American Heart Association to support her research project “The role of mRNA deadenylation in translational repression during development." Post-transcriptional regulation is important for controlling protein synthesis (translation) in spatial and temporal context. Disruption of post-transcriptional regulation can cause human diseases, including neuronal disease, heart hypertrophy, and infertility. Wang is studying mRNA silencing elicited by the process called deadenylation using a model organism C.
Wang's research will delineate a new mechanism regulating activation of deadenylation machinery. Wang anticipates that this mechanism involving conserved proteins will also be active in human cells and might provide new targets for therapeutic intervention in related heart diseases.