Faculty and Staff

Brooke Martin

Brooke Martin

Research. Associate Professor of Chemistry and Biochemistry

Office: Chem 215
Email: brooke.martin@umontana.edu

Courses

Chem541 – Environmental Chemistry

BCH480 – Advanced Biochemistry (50 students)

BCH486 – Advanced Biochemistry Research Laboratory (10-15 students)

Chem123 – Introduction to Organic and Biochemistry (130 students)

Chem 124 – Introduction to Organic and Biochemistry Laboratory (90 students)

Chem 311 - Quantitative Analysis (35 students)

Personal Summary

With a four year industry hitus  in the Paint and Pigment industry working for Dulux, ICI, Australia Dr. Martin's research has been in the area of metals - primarily toxic metals in biological systems.  This includes research in the laboratory of Dr. Peter Lay at the University of Sydney synthesizing novel Cr(V) compounds and studying chromium and vanadium mutation rates in Salmonella Typhimurium as well as a PhD with Dr. Karen Wetterhahn at Dartmouth College in 1998, looking into the toxicity and metabolism of chromium, arsenic and cadmium compounds in human lung cells. From 1998-2000 she was an American Heart Association Postdoctoral fellow in the Division of Cell Biology at the University of Utah Medical School, studying iron and copper metabolism and the way toxic metals could utilise essential metal delivery systems. Dr. Martin moved to the University of Montana in 2000 as a postdoctoral fellow in the laboratory of Dr. Kent Sugden. She is now a Research Associate Professor in the Department of Chemistry. 

Education

Bachelor of Science (Hons); The University of Sydney, Australia 

PhD, Dartmouth College, NH, USA

American Heart Association Post-doctoral fellow; The University of Utah, UT, USA

Research Interests

My research interest remains the study of toxic metals in biological systems, particularly with regard to modifcations of DNA and its consequences, including repair and carcinogenesis.  

Field of Study

Toxic metals in biologicals systems and the cellular response to DNA modification. 

Selected Publications

Shafirovich, V. Kropachev K, Anderson, T. Lie Z, Kolbanovkiy M., Sugden, K, Martin, B. and Geacintov N.  Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA. 2016  J. Biol Chem. 291, 5309-5319.

Gremaud, J.G., Martin, B.D., Sugden, K.D.  2010 Influence of substrate complexity on the diastereo-selective formation of spiroiminodihydantoin and guanidinohydantoin from chromate oxidation. Chem. Res. Tox. 23, 379-385. 

Bergquist ER, Fischer RJ, Sugden KD, Martin BD. 2009 “Inhibition by methylated organo-arsenicals of the respiratory 2-oxo-acid dehydrogenases.” J. Organomet. Chem. 2009  694(6):973-980.

Hailer MK, Slade PG, Martin BD, Rosenquist TA and Sugden KD 2005 "Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2  2" DNA Repair 4(1) 41-50.

Hailer MK, Slade PG, Martin BD, and Sugden KD 2005 “Nei Deficient Escherichia coli Are Sensitive to Chromate and Accumulate the Oxidized Guanine Lesion Spiroiminodihydantoin” Chem. Res. Toxicol. 18(9), 1378-1383. and cover

Sugden KD, Campo CK, and Martin BD. 2001 “Direct Oxidation of Guanine and 7,8-dihydro-8-oxo-Guanine by a High Valent Chromium Complex” Chem. Res. Toxicol. 14(9) 1315-1322

Martin BD, Schoenhard JA and Sugden K D. 1998 “Hypervalent Chromium Mimics Reactive Oxygen Species as Measured by the Oxidant-Sensitive Dyes 2',7'-Dichlorofluorescein and Dihydrorhodamine” Chem. Res. Toxicol., 11(12) 1402-1410.

Publications

Ardon OA, Kaplan J and Martin BD. 2002 “Iron Uptake in Yeast“ in Molecular and Cellular Iron Transport Marcell Dekker Templeton D ed. Chapter II.2

Sugden KD, Campo CK, and Martin BD. 2001 “Direct Oxidation of Guanine and 7,8-dihydro-8-oxo-Guanine by a High Valent Chromium Complex” Chem. Res. Toxicol. 14(9) 1315-1322

Martin BD, Schoenhard JA and Sugden K D. 1998 “Hypervalent Chromium Mimics Reactive Oxygen Species as Measured by the Oxidant-Sensitive Dyes 2',7'-Dichlorofluorescein and Dihydrorhodamine” Chem. Res. Toxicol., 11(12) 1402-1410.

Teaching Experience

Bio-Inorganic Chemistry; Biochemistry; Analytical Chemistry; Metal Toxicology