Faculty and Staff
BS, Fort Lewis College, Durango, CO
PhD, Montana State University, Bozeman, MT
NIH/NIAID Adjuvant Development Program.
The goal of this contract is development of new adjuvant for use in a Rapid Acting Vaccine for influenza virus
.NIH/NAIAD Innate Immune Receptors and Adjuvant Discovery: Identification of Novel Th17 inducing CLR Agonists as Vaccine Adjuvants.
NIH/NIAID. Innate Immune Receptors and Adjuvant Discovery.
The goal of the program was to develop novel synthetic TLR4 agonists, the aminoakylglucosaminide phosphates, for use as mucosal adjuvant and inducer of innate protection of the airways against infectious challenge.
Kendal Ryter and Tom Livinghouse, “[2-((Trimethylsilyl)methyl)prop-2-enyl]-lithium. A Versatile Reagent for the Synthesis of 2-Substituted Propenylsilanes” J. Org. Chem. 1997, 62, 4842-4844
Kendal Ryter and Tom Livinghouse, “Dichloro(2,2,2-trifluoroethoxy)oxovanadium(V). A Remarkably Effective Reagent for Promoting One-Electron Oxidative Cyclization and Unsymmetrical Coupling of Silyl Enol Ethers”J. Am. Chem. Soc. 1998, 120, 2658-2659
Peter R. Guzzo,*, Ronald N. Buckle, Ming Chou, Sean R. Dinn, Michael E. Flaugh, Anton D. Kiefer, Jr., Kendal T. Ryter, Anthony J. Sampognaro, Steven W. Tregay, and Yao-Chang Xu, Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and Several Fluorinated Derivatives via [3,3]-Sigmatropic Rearrangement of O-Aryloximes, J. Org. Chem., 2002, 68, 770-778
Bazin, H.G., Bess, L.S, Livesay, M.T., Ryter, K.T., Johnson, C.L., Arnold, J.S., and Johnson, D.A., “New synthesis of glycolipid immunostimulants RC-529 and CRX-524”, Tetrahedron Lett., 2006, 47(13), 2087-2092
Bryan H. Norman, Timothy I. Richardson, Jeffrey A. Dodge, Lance A. Pfeifer, Gregory L. Durst, Yong Wang, Jim D. Durbin,a Venkatesh Krishnan, Sean R. Dinn, Shengquan Liu, John E. Reilly and Kendal T. Ryter, “Benzopyrans as selective estrogen receptor b agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring”, Bioorganic & Medicinal Chemistry Letters., 2007, 17, 5082-5085
Bazin H.G., Murray, T.J., Bowen, W.S., Mozaffarian, A., Fling, S.P., Bess L.S., Livesay M.T., Arnold J.S., Johnson C.L., Ryter K.T., Johnson C.L., Cluff C.W., Evans J.T., Johnson D.A. The ‘ethereal’ nature of TLR4 agonism and antagonism the AGP class of lipid A mimetics, Bioorg. Med. Chem. Lett., 2008, 18, 5350-5454
Didierlaurent, A. M., Collignon, C., Bourguignon, P., Wouters, S., Fierens, K., Fochesato, M., Dengouga, N., Langlet, C., Malissen, B., Lambrecht, B. N., Garcon, N., Van Mechelen, M., Morel, S. (acknowledgement: Ryter), Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells, J. Immunol. 2014, 193, 1920-1930
Khalaf, J. K., Bowen, W.S., Ryter, K.T., Bazin H.G., Evans J.T., Johnson D.A. Characterization of TRIF Selectivity in the AGP Class of Lipid A Mimetics: Role of Secondary Lipid Chains, Bioorg. Med. Chem. Lett. 2015, 25(3), 547-553
synthetic chemistry, process safety, project management, cGMP and ICH-Q7A guidelines, contract manufacturing
Albany Molecular Research, Albany, NY
GlaxoSmithKline Biologicals, Hamilton, MT