Research Faculty

Kendal Ryter

Kendal Ryter

Associate Research Faculty

Office: HS 304A
Email: kendal.ryter@mso.umt.edu

Curriculum Vitae

Education

BS, Fort Lewis College, Durango, CO

PhD, Montana State University, Bozeman, MT; Advisor Professor Tom Livinghouse

Projects

My research interests center on the discovery and developmetnt of immune modifying compounds for application t ovaccine research and autoimmune diseases. I'm interested in Toll receptors (TLR) and pattern recognition receptors (PRR). My group will focus on everything from crystal structure assisted molecule design, library synthesis, SAR, synthetic route optimization and risk assesment and preclinical supply including PK/ADME determinations.

  • HHSN272200900008C/NO1-AI-8009

NIH/NIAID Adjuvant Development Program. 

The goal of this contract is development of new adjuvant for use in a Rapid Acting Vaccine for influenza virus

  • HHSN272200900036C/N01-AI-90036                       

NIH/NAIAD Innate Immune Receptors and Adjuvant Discovery: Identification of Novel Th17 inducing CLR Agonists as Vaccine Adjuvants. 

My current work is focused on the discovery of novel C-type lectin receptor (CLR) agonits capable of eliciting a TH17 immune response for vaccine development against Mycobacterium tuberculosis. I am the project manager on BAA-NIAID-DAIT-NIHAI2013168. I am the primary author for two patent applications describing novel MINCLE active ligand scaffolds.

  • HHSN266200400008C/N01-AI-40008,

NIH/NIAID. Innate Immune Receptors and Adjuvant Discovery.

The goal of the program was to develop novel synthetic TLR4 agonists, the aminoakylglucosaminide phosphates, for use as mucosal adjuvant and inducer of innate protection of the airways against infectious challenge.

Publications

  1. Kendal Ryter and Tom Livinghouse, “[2-((Trimethylsilyl)methyl)prop-2-enyl]-lithium. A Versatile Reagent for the Synthesis of 2-Substituted Propenylsilanes J. Org. Chem. 1997, 62, 4842-4844
  2. Kendal Ryter and Tom Livinghouse, “Dichloro(2,2,2-trifluoroethoxy)oxovanadium(V). A Remarkably Effective Reagent for Promoting One-Electron Oxidative Cyclization and Unsymmetrical Coupling of Silyl Enol EthersJ. Am. Chem. Soc. 1998, 120, 2658-2659
  3. Peter R. Guzzo,*, Ronald N. Buckle, Ming Chou, Sean R. Dinn, Michael E. Flaugh, Anton D. Kiefer, Jr., Kendal T. Ryter, Anthony J. Sampognaro, Steven W. Tregay, and Yao-Chang Xu, Preparation of 8-Amido-2-dimethylamino-1,2,3,4-tetrahydro-2-dibenzofurans and Several Fluorinated Derivatives via [3,3]-Sigmatropic Rearrangement of O-Aryloximes, J. Org. Chem., 2002, 68, 770-778
  4. Bazin, H.G., Bess, L.S, Livesay, M.T., Ryter, K.T., Johnson, C.L., Arnold, J.S., and Johnson, D.A., “New synthesis of glycolipid immunostimulants RC-529 and CRX-524”, Tetrahedron Lett., 2006, 47(13), 2087-2092
  5. Bryan H. Norman, Timothy I. Richardson, Jeffrey A. Dodge, Lance A. Pfeifer, Gregory L. Durst, Yong Wang, Jim D. Durbin,a Venkatesh Krishnan, Sean R. Dinn, Shengquan Liu, John E. Reilly and Kendal T. Ryter, “Benzopyrans as selective estrogen receptor b agonists (SERBAs). Part 4: Functionalization of the benzopyran A-ring”, Bioorganic & Medicinal Chemistry Letters., 2007, 17, 5082-5085
  6. Bazin H.G., Murray, T.J., Bowen, W.S., Mozaffarian, A., Fling, S.P., Bess L.S., Livesay M.T., Arnold J.S., Johnson C.L., Ryter K.T., Johnson C.L., Cluff C.W., Evans J.T., Johnson D.A. The ‘ethereal’ nature of TLR4 agonism and antagonism the AGP class of lipid A mimetics, Bioorg. Med. Chem. Lett., 2008, 18, 5350-5454
  7. Didierlaurent, A. M., Collignon, C., Bourguignon, P., Wouters, S., Fierens, K., Fochesato, M., Dengouga, N., Langlet, C., Malissen, B., Lambrecht, B. N., Garcon, N., Van Mechelen, M., Morel, S. (acknowledgement: Ryter), Enhancement of Adaptive Immunity by the Human Vaccine Adjuvant AS01 Depends on Activated Dendritic Cells, J. Immunol. 2014, 193, 1920-1930
  8. Khalaf, J. K., Bowen, W.S., Ryter, K.T., Bazin H.G., Evans J.T., Johnson D.A. Characterization of TRIF Selectivity in the AGP Class of Lipid A Mimetics: Role of Secondary Lipid Chains, Bioorg. Med. Chem. Lett. 2015, 25(3), 547-553
  9. Alyson J Smith,  Shannon Miller,  Cassandra Buhl,  Robert Child,  Margaret Whitacre,  Roman Schoener,  George Ettenger, David Burkhart,  Kendal Ryter and  Jay T Evans.  Species-specific structural requirements of alpha-branched trehalose diester Mincle agonists. Front. Immunol. - Vaccines and Molecular Therapeutics. Submitted on: 26 Jun 2018.
  10. Smith AJ, Graves B, Child R, Rice PJ, Ma Z, Lowman DW, Ensley HE, Ryter KT, Evans JT, Williams DL. Immunoregulatory Activity of the Natural Product Laminarin Varies Widely as a Result of Its Physical Properties. J Immunol. 2018 Jan 15;200(2):788-799. PubMed PMID: 29246954; PubMed Central PMCID: PMC5760317.

 

Specialized Skills

Mass spectrometry, synthetic chemistry, process safety, project management, cGMP and ICH-Q7A guidelines, contract manufacturing 

Professional Experience

  1. 1998 - 1999 Senior Research Scientist, AMRI, Albany , NY
  2. 1999 - 2002 Senior Research Scientist I, AMRI, Albany, NY
  3. 2002 - 2003 Senior Research Scientist II, AMRI, Albany , NY
  4. 2003 - 2008 Process Development Scientist II, Corixa, Hamilton, MT
  5. 2005 - 2008 Principal Scientist, GlaxoSmithKline, Hamilton, MT
  6. 2008 - 2015 Investigator, GlaxoSmithKline, Hamilton, MT
  7. 2016 - Associate Research Faculty, University of Montana, Missoula , MT
  8. 2016 - Co-founder, Board Chair, VP Manufacturing and Development, Inimmune, Missoula, MT