We study the importance of spatial organization of regulatory protein/RNA complexes within the cytoplasm. Our model organism is the nematode, C. elegans. C. elegans reproduction is sustained by germ cells that give rise to eggs and sperm. Our lab investigates how the germ cell RNA regulatory machinery is organized in cytoplasmic organelles called P granules (or germ granules). The strategy of assembling important regulators of RNA metabolism in cytoplasmic foci is conserved across species, and we anticipate that our findings will shed light on the functions of conserved regulators in development and disease.
C. elegans germ cell nuclei (cyan) are surrounded by germ granules (red).
5/16/16 - New Lab Members - Nick Day decided to join the lab after first-year rotations in CMMB graduate program. Welcome on board, Nick! Emily Osterli and Ella Baumbarten will be working in the lab as undegraduate researchers. Looking forward to the exciting summer ahead.
4/15/16 - Paper - A review of C. elegans germ cell developmental decisions by Ekaterina Voronina and David Greenstein was published in eLS.
4/4/16 - Paper - A Preview article published in Developmental Cell discusses a novel and exciting role of small RNAs in Drosophila patterining.
3/30/16 - Award - Mary Ellenbecker received University of Montana Small Grant Award from the Office of Research and Sponsored Programs. Congrats, Mary!
12/12/15 - ASCB meeting - RNA granule assembly and cellular functions were discussed and the annual meeting of the Society for Cell Biology in San Diego, CA.