We study the importance of spatial organization of regulatory protein/RNA complexes within the cytoplasm. Our model organism is the nematode, C. elegans. C. elegans reproduction is sustained by germ cells that give rise to eggs and sperm. Our lab investigates how the germ cell RNA regulatory machinery is organized in cytoplasmic organelles called P granules (or germ granules). The strategy of assembling important regulators of RNA metabolism in cytoplasmic foci is conserved across species, and we anticipate that our findings will shed light on the functions of conserved regulators in development and disease.
C. elegans germ cell nuclei (cyan) are surrounded by germ granules (red).
6/11/18 - Ph.D. candidate - Xiaobo Wang successfully passed the oral qualifying examination and advanced to Ph.D. candidacy. Congrats, Xiaobo!
4/27/18 - Award - Xiaobo Wang received a Montana Academy of Sciences Student Research Award for proposed experiments to detect in vivo interaction between stem cell regulator FBF-2 and its cofactor DLC-1. Xiaobo is on a roll!!!
4/27/18 - UMCUR - Ella Baumgarten, Ben Hickey, and Emily Osterli presented their research progress at the UM Conference for Undergraduate Research.
4/23/18 - Award - Xiaobo Wang was awarded a prestigious predoctoral fellowship from the American Heart Association to support her investigation of post-transcriptional regulation in stem cells. Congrats, Xiaobo!
4/20/18 - UM GradCon - Xiaobo Wang presented her research at the UM Graduate Conference.
12/20/17 - Ph.D. candidate - Nick Day successfully passed the oral qualifying examination and advanced to Ph.D. candidacy. Congrats, Nick!
12/2-6/17 - ASCB meeting - RNA granule assembly and cellular functions were discussed at the annual meeting of the American Society for Cell Biology in Philadelphia, PA.