Faculty Profile


David Holley

David Holley

Molecular Computation Core Facility Manager

Email: dave.holley@umontana.edu
Office: Skaggs 482

Curriculum Vitae

Publications

Maolanon, A.R., Risgaard, R., Wang, S.-Y., Snoep, Y., Papangelis, A., Yi, F., Holley, D., Barslund, A.F., Svenstrup, N., Hansen, K.B. (2017). Subtype-Specific Agonists for NMDA Receptor Glycine Binding Sites. ACS Chem. Neurosci. 8, 1681–1687.

McClelland, L., Steele, H., Whitby, F., Mou, T.C., Holley, D., Ross, J. B. A., Sprang, S., Bowler, B., (2016). “Cytochrome c Can Form a Well-Defined Binding Pocket for Hydrocarbons.” JACS 138(51):16770–16778.

Wang, H., Rascoe, A., Holley, D. C., Gouaux, E., Kavanaugh, M. P. (2013). “Novel dicarboxylate selectivity in an insect glutamate transport homologue.” PLoS ONE  8(8): e74907.

Leary, G. P., Holley, D. C., Stone, E. F., Lyda, B., Kalachev, L., Kavanaugh, M. P. (2011). “The central cavity in trimeric glutamate transporters restricts ligand diffusion.” PNAS 108(36):14980-85.

Holley, D. C. and Kavanaugh, M. P. (2009). "Interactions of alkali cations with glutamate transporters." Philos Trans R Soc Lond B Biol Sci 364(1514): 155-61.

Sun, W., Hoffman, K. M., Holley, D. C., Kavanaugh, M. P. (2011). ”Specificity and actions of a new benzylaspartate inhibitor of glutamate transport at the Schaffer collateral-CA1 pyramidal cell synapse.” PLoS ONE 6(8): e23765.

Hassani, M., Cai, W., Koelsch, K. H., Holley, D. C., Rose, A. S., Olang, F., Lineswala, J. P., Holloway, W. G., Gerdes, J. M., Behforouz, M., Beall, H. D. (2008). "Lavendamycin antitumor agents: structure-based design, synthesis, and NAD(P)H:quinone oxidoreductase 1 (NQO1) model validation with molecular docking and biological studies." J Med Chem 51(11): 3104-15.

Leary, G. P., Stone, E. F., Holley, D. C., Kavanaugh, M. P. (2007). "The glutamate and chloride permeation pathways are colocalized in individual neuronal glutamate transporter subunits." J Neurosci 27(11): 2938-42.

Hassani, M., Cai, W., Holley, D. C., Lineswala, J. P., Maharjan, B. R., Ebrahimian, G. R., Seradj, H., Stocksdale, M. G., Mohammadi, F., Marvin, C. C., Gerdes, J. M., Beall, H. D., Behforouz, M.. (2005). "Novel lavendamycin analogues as antitumor agents: synthesis, in vitro cytotoxicity, structure-metabolism, and computational molecular modeling studies with NAD(P)H:quinone oxidoreductase 1." J Med Chem 48(24): 7733-49.

Poss, M., Holley, D. C., Biek, R., Cox, H., Gerdes, J. (2004). "Development of a homology model for clade A human immunodeficiency virus type 1 gp120 to localize temporal substitutions arising in recently infected women." J Gen Virol 85(Pt 6): 1479-84.