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We study the importance of spatial organization of regulatory protein/RNA complexes within the cytoplasm.  Our model organism is the nematode, C. elegans.  C. elegans reproduction is sustained by germ cells that give rise to eggs and sperm.  Our lab investigates how the germ cell RNA regulatory machinery is organized in cytoplasmic organelles called P granules (or germ granules).  The strategy of assembling important regulators of RNA metabolism in cytoplasmic foci is conserved across species, and we anticipate that our findings will shed light on the functions of conserved regulators in development and disease.

C. elegans germ cell nuclei (cyan) are surrounded by germ granules (red).

C. elegans germ cell nuclei (cyan) are surrounded by germ granules (red).

Recent Lab News

10/9/18 - Germ Cell Meeting - Mary Ellenbecker, Xiaobo Wang and Ekaterina Voronina presented the lab research at the Germ Cell Meeting at Cold Spring Harbor Labs, NY.

9/17/18 - Award - Nick Day received a Travel Award to attend ASCB annual meeting. Super-productive fall for Nick!

9/14/18 - Publication - Nick Day's manuscript on C. elegans DLC-1 RIP-seq was accepted for publication in FEBS Letters. Mary Ellenbecker contributed to this study. Congrats, Nick and Mary! DOI: 10.1002/1873-3468.13259

8/30/18 - Upcoming Conference Talk - Nick Day's abstract has been selected for a minisymposium talk at the annual meeting of the American Society for Cell Biology. If you're reading this, make sure to go to ASCB and hear Nick's story.

8/25/18 - New Lab Member - Mikaya Terzo started working in the lab as an undergraduate researcher. Welcome Mikaya!!!

6/11/18 - Ph.D. candidate - Xiaobo Wang successfully passed the oral qualifying examination and advanced to Ph.D. candidacy. Congrats, Xiaobo!

4/27/18 - Award - Xiaobo Wang received a Montana Academy of Sciences Student Research Award for proposed experiments to detect in vivo interaction between stem cell regulator FBF-2 and its cofactor DLC-1. Xiaobo is on a roll!!!

4/27/18 - UMCUR - Ella Baumgarten, Ben Hickey, and Emily Osterli presented their research progress at the UM Conference for Undergraduate Research.

4/23/18 - Award - Xiaobo Wang was awarded a prestigious predoctoral fellowship from the American Heart Association to support her investigation of post-transcriptional regulation in stem cells. Congrats, Xiaobo!

4/20/18 - UM GradCon - Xiaobo Wang presented her research at the UM Graduate Conference.